Referenced in: none

Automatically associated channels: Kir2.3

Title: 4-Aminopyridine derivatives with antiamnesic activity.

Authors: A Andreani, A Leoni, A Locatelli, R Morigi, M Rambaldi, C Pietra, G Villetti

Journal, date & volume: , 2000 Jan , 35, 77-82

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10733605

Abstract
Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of improving their antiamnesic activity, is here described. In two of these compounds 4-AP is connected to 4-aminobutyric acid (GABA), whereas in the third it is connected to 2-indolinone, i.e., the skeleton of linopirdine, another Ach enhancing agent. The new compounds showed potent antiamnesic activity in comparison with piracetam.