Referenced in: none

Automatically associated channels: Kv2.1

Title: The outer envelope protein OEP24 from pea chloroplasts can functionally replace the mitochondrial VDAC in yeast.

Authors: T Röhl, M Motzkus, J Soll

Journal, date & volume: FEBS Lett., 1999 Nov 5 , 460, 491-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10556523

Abstract
The chloroplastic outer envelope protein OEP24 from pea forms a high-conductance low specificity solute channel as shown by in vitro studies. In order to establish its function also in an in vivo-like system, the gene encoding OEP24 was transformed into a yeast strain which lacks the general mitochondria solute channel porin, also known as voltage-dependent anion channel (VDAC). Transformation of the yeast VDAC(-) strain with the OEP24 gene resulted in the recovery of a phenotype indistinguishable from the wild-type. The OEP24 polypeptide is targeted to the mitochondrial outer membrane in this heterologous system. We conclude that OEP24 forms a solute channel in pea chloroplasts in planta.