Referenced in: none

Automatically associated channels: Kv11.1

Title: Sulfonylureas blockade of neural and cardiac HERG channels.

Authors: B Rosati, M Rocchetti, A Zaza, E Wanke

Journal, date & volume: FEBS Lett., 1998 Nov 27 , 440, 125-30

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9862440

Abstract
The human ether-a-go-go-related gene (herg) encodes a K+ current (I(HERG)) which plays a fundamental role in heart excitability and in neurons by contributing to action potential repolarization and to spike-frequency adaptation, respectively. In this paper we show that I(HERG), recorded in neuroblastoma cells and guinea-pig ventricular myocytes, was reversibly inhibited by the K(ATP) channel blocker glibenclamide (IC50 = 74 microM). The voltage and use dependence of glibenclamide blockade were also evaluated. Another sulfonylurea, glimepiride, had less effective results in blocking I(HERG). The findings of this study are relevant to the interpretation of glibenclamide effects on cellular electrophysiology and suggest that oral antidiabetic therapy with sulfonylureas may contribute to iatrogenic QT prolongation and related arrhythmias.