Referenced in: none

Automatically associated channels: ClC4

Title: Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons.

Authors: L Bianchi, D M Miller, A L George

Journal, date & volume: Neurosci. Lett., 2001 Feb 23 , 299, 177-80

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11165764

Abstract
In this study, we report the complete cDNA sequence, genomic organization and expression pattern of the Caenorhabditis elegans ClC chloride channel gene, clh-6. Two different types of reporter gene fusions suggest that clh-6 expression is restricted to two gamma-aminobutyric acid-ergic RME neurons. These results are in striking contrast with the wide tissue distribution of messenger RNA for the related mammalian isoforms, CIC-6 and CIC-7. The restricted expression pattern of clh-6 provides a unique opportunity to study the biological function of a neuronal CIC chloride channel.