Referenced in: none

Automatically associated channels: Kir2.3

Title: TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL.

Authors: X Z Xu, F Chien, A Butler, L Salkoff, C Montell

Journal, date & volume: Neuron, 2000 Jun , 26, 647-57

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10896160

Abstract
TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-related subunit has previously been proposed to function with TRPL. Here, we identify such a subunit, TRPgamma. We show that TRPgamma is highly enriched in photoreceptor cells and preferentially heteromultimerizes with TRPL in vitro and in vivo. The N-terminal domain of TRPgamma dominantly suppressed the TRPL-dependent photoresponse, indicating that TRPgamma-TRPL heteromultimers contribute to the photoresponse. While TRPL and TRPgamma homomultimers are constitutively active, we demonstrate that TRPL-TRPgamma heteromultimers form a regulated phospholipase C- (PLC-) stimulated channel.