Referenced in: none

Automatically associated channels: Kir2.3

Title: Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes.

Authors: Yusong He, Qin Pan, Jun Li, Huaizhi Chen, Qinshu Zhou, Kui Hong, Ramon Brugada, Guillermo J Perez, Pedro Brugada, Yi-Han Chen

Journal, date & volume: FEBS Lett., 2008 Jun 25 , 582, 2338-42

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18503768

Abstract
Inward rectifier potassium Kir2.x channels mediate cardiac inward rectifier potassium currents (I(K1)). As a subunit of Kir2.x, the physiological role of Kir2.3 in native cardiomyocytes has not been reported. This study shows that Kir2.3 knock-down remarkably down-regulates Kir2.3 expression (Kir2.3 protein was reduced to 19.91+/-3.24% on the 2nd or 3rd day) and I(K1) current densities (at -120 mV, control vs. knock-down: -5.03+/-0.24 pA/pF, n=5 vs. -1.16+/-0.19 pA/pF, n=7, P<0.001) in neonatal rat cardiomyocytes. The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes.