Referenced in: none

Automatically associated channels: ClC4

Title: [A case of small cell lung cancer with paraneoplastic cerebellar degeneration and anti-voltage-gated calcium channel antibody]

Authors: S Shirai, N Sukoh, H Yamamoto, I Suzuki, A Kamimura, K Yoshida, A Suzuki, M Inoue, N Watanabe

Journal, date & volume: , 2001 Jan , 39, 40-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11296385

Abstract
A 55-year-old man presenting with 4 weeks of progressive dysarthria, gait ataxia and vertigo was admitted to our hospital. Chest X-ray films revealed a mass shadow in the right upper lobe of the lung, and transbronchial brushing specimens showed small-cell carcinoma. Extensive examination revealed metastatic lesions in the mediastinal lymph nodes and liver, but brain MRI showed no findings suggestive of metastasis or atrophy. A diagnosis of PCD associated with SCLC was made, and the patient had a high titer of anti-P/Q-type VGCC antibody. He was treated by chemotherapy and radiation therapy, which resulted in a transient improvement in the PCD symptoms.