Referenced in: none

Automatically associated channels: Kir2.3

Title: ADP receptors in platelet activation and aggregation.

Authors: M F Hoylaerts, C Oury, E Toth-Zsamboki, J Vermylen

Journal, date & volume: Platelets, 2000 Sep , 11, 307-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11083454

Abstract
ADP plays a central role in platelet aggregation. Activation of platelets via ADP proceeds via three membrane receptor proteins, two of which are coupled to a G protein and the third one constituting an ion channel mediating rapid Ca2+-influx. Via Ca2+-mobilization, the Gq-coupled P2Y1 receptor acts in concert with the Gi-coupled P2TAC receptor, which functions by lowering intracellular cAMP levels. The importance of Ca2+-influx via the P2X1 ion channel remains to be elucidated.