Channelpedia

PubMed 12007740


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir1.1



Title: Regulation of ROMK channels by protein tyrosine kinase and tyrosine phosphatase.

Authors: Wen-Hui Wang, Dao-Hong Lin, Hyacinth Sterling

Journal, date & volume: Trends Cardiovasc. Med., 2002 Apr , 12, 138-42

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12007740


Abstract
Renal outer medulla K (ROMK) channels play an important role in K recycling in the thick ascending limb and in K secretion in the cortical collecting duct. ROMK1, a member of the ROMK family, has been shown to be a substrate for protein tyrosine kinase (PTK). The tyrosine phosphorylation of ROMK channels increases with low dietary K intake and decreases with high dietary K intake. Moreover, the stimulation of tyrosine phosphorylation of ROMK1 channels decreases the number of K channels by facilitating endocytosis. In contrast, the stimulation of tyrosine dephosphorylation increases the number of ROMK1 channels in the cell membrane by enhancing membrane insertion. PTK and tyrosine phosphatase-induced regulation of ROMK1 channels play a key role in mediating the effect of the dietary K intake on renal K secretion.