Referenced in: none

Automatically associated channels: ClC4

Title: Deletion of a Vibrio cholerae ClC channel results in acid sensitivity and enhanced intestinal colonization.

Authors: Yanpeng Ding, Matthew K Waldor

Journal, date & volume: Infect. Immun., 2003 Jul , 71, 4197-200

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12819118

Abstract
ClC chloride channels are found in all three kingdoms of life though little is known about their functions in prokaryotes. Here we investigated the role of a Vibrio cholerae ClC channel in acid resistance and intestinal colonization. The putative V. cholerae ClC channel was found to confer mild resistance to acid when pH was adjusted with HCl, but not with other acids. Surprisingly, a ClC channel deletion mutant exhibited enhanced intestinal colonization in infant mice.