Channelpedia

PubMed 12417318


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav3.1 , Slo1



Title: Gating of the expressed Cav3.1 calcium channel.

Authors: L' Lacinová, N Klugbauer, F Hofmann

Journal, date & volume: FEBS Lett., 2002 Nov 6 , 531, 235-40

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12417318


Abstract
Intramembrane charge movement originating from Cav3.1 (T-type) channel expressed in HEK 293 cells was investigated. Ion current was blocked by 1 mM La3+. Charge movement was detectable for depolarizations above approximately -70 mV and saturated above +60 mV. The voltage dependence of charge movement followed a single Boltzmann function with half-maximal activation voltage +12.9 mV and +12.3 mV and with slopes of 22.4 mV and 18.1 mV for the ON- and OFF-charge movement, respectively. Inactivation of I(Ca) by prolonged depolarization pulse did not immobilize intramembrane charge movement in the Cav3.1 channel.