Channelpedia

PubMed 19393632


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: ClvC4 , ClvC7



Title: CLC-7: a potential therapeutic target for the treatment of osteoporosis and neurodegeneration.

Authors: Qingxiao Zhao, Qun Wei, Aimin He, Ruokun Jia, Yongtao Xiao

Journal, date & volume: Biochem. Biophys. Res. Commun., 2009 Jul 3 , 384, 277-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19393632


Abstract
CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.