Referenced in: none

Automatically associated channels: HCN1

Title: [NMR study on solution configuration of mHCN1 pore peptide]

Authors: Tao Sui, Han-Gang Yu, Hong-Yu Hu, Yan-Hong Shi, Guo-Qiang Song

Journal, date & volume: Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao, 2003 Jan , 35, 59-63

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12518229

Abstract
Spin systems for amino acid residues in mHCN1 pore region peptide have been identified through analysis of 2D NMR spectra. The sequence-specific assignment of spin systems was obtained by NOEs correlation in WET-NOESY spectra, and the complete assignment of proton resonances for backbone and side chain has been achieved. CNS software was used to calculate the structure of mHCN1 19 aa peptide. The results show that an alpha-helix from residue 10 to residue 13 is formed within the pore region. The results of NMR study on mHCN1 pore peptide provide the basis for further understanding the mechanism of ion selectivity of channels.