Referenced in: none

Automatically associated channels: ClC4

Title: A two-holed story: structural secrets about ClC proteins become unraveled?

Authors: Elena Babini, Michael Pusch

Journal, date & volume: , 2004 Oct , 19, 293-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15381758

Abstract
ClC Cl(-) channels are found in almost all organisms, ranging from bacteria to mammals, in which nine Cl(-) channels belonging to the ClC family have been identified. The biophysical properties and physiological functions of ClC Cl(-) channels have been extensively reviewed. In this short review, we will focus on recent results obtained on the X-ray structure and functional properties of the prokaryotic ClC-ec1 protein and some results obtained on the role of the cytoplasmic COOH terminus of mammalian ClCs.