Referenced in: none

Automatically associated channels: Kv2.1

Title: Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4.

Authors: Hyosang Lee, Tohko Iida, Atsuko Mizuno, Makoto Suzuki, Michael J Caterina

Journal, date & volume: J. Neurosci., 2005 Feb 2 , 25, 1304-10

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15689568

Abstract
Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4-/- mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation in vivo. On a thermal gradient, TRPV4-/- mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34 degrees C, TRPV4-/- mice exhibited a strong preference for 34 degrees C. TRPV4-/- mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4-/- and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo.