Referenced in: none

Automatically associated channels: Kv11.1

Title: [Expression of human ether-a-go-go-related gene in laryngeal carcinoma].

Authors: Dashuai Liang, Liping Wang, Wenyue Ji

Journal, date & volume: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2015 Dec , 29, 2160-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/27093819

Abstract
To study the expression of human ether-α-go-go-related gene (herg) and hERG protein expressed by the gene in laryngeal carcinoma compared with the control group(mucosa adjacent to cancer of 2 cm).Expression of herg and hERG protein was detected by immunohistochemistry (SP) and real-time PCR in resected tissue of laryngeal carcinoma and mucosa adjacent to cancer of 2 cm.(1) By immunohistochemistry, the positive expression rate of hERG in laryngeal carcinoma was 76.7% (23/30), while it was 10.0% (2/20) in mucosa adjacent to cancer of 2 cm, the difference between which was statistically significant (P < 0.05). (2) By real-time PCR, the expression level of herg mRNA in laryngeal carcinoma is 2.25 times higher than that in mucosa adjacent to cancer of 2 cm.Herg is highly expressed in tissue of laryngeal carcinoma, and it may be have some relevance to the happening and development of laryngeal carcinoma.