Referenced in: none

Automatically associated channels: TRP

Title: [The progress of TRP channels in structural studies].

Authors: Di-Jing Shi, Ke-Wei Wang

Journal, date & volume: Sheng Li Ke Xue Jin Zhan, 2014 Dec , 45, 401-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25872344

Abstract
Transient receptor potential (TRP) channels are a super-family of nonselective cation channels that play critical roles in the responses to various environmental changes and stimuli. Over the past 10 years much progress has been made in the structural studies of TRP channels. To date, the structures of 5 full-length TRP channels and their 11 cytoplasmic domains have been determined. These structural insights enhance our understanding of TRP channel gating, assembly and regulation. In this review, the structures of TRP channels are summarized with an emphasis on the progress made during the last two years.