Referenced in: none

Automatically associated channels: Kv11.1

Title: Dopamine receptor agonists differ in their actions on cardiac ion channels.

Authors: Raymond S Hurst, Nicole R Higdon, Judy A Lawson, Michael A Clark, Karen L Rutherford-Root, William G McDonald, Joseph V Haas, James P McGrath, Martin D Meglasson

Journal, date & volume: Eur. J. Pharmacol., 2003 Dec 15 , 482, 31-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/14660002

Abstract
Four dopamine receptor agonists used for the treatment of Parkinson's disease (apomorphine, pergolide, ropinirole and sumanirole) were evaluated for the ability to block human ether-a-go-go related gene (hERG) K(+) channels and to modify the duration of canine Purkinje fiber action potentials. Apomorphine, pergolide and ropinirole blocked the hERG-mediated currents with IC(50) values of 2.4, 0.12 and 1.2 microM, respectively. When evaluated in an action potential duration assay, pergolide significantly shortened action potential duration at 90% repolarization (APD(90)) whereas apomorphine and ropinirole significantly prolonged repolarization. Sumanirole only partially blocked hERG K(+) channels at the highest tested concentration (10 microM) and did not modify action potential duration over the tested concentration range (0.65-65 microM). Taken together, these data provide evidence that dopamine receptor agonists developed for the treatment of Parkinson's disease differentially influence hERG K(+) channel function and cardiac action potential duration.