Referenced in: none

Automatically associated channels: TASK1

Title: Protein-lipid interactions critical to replication of the influenza A virus during infection.

Authors: Petr Chlanda, Joshua Zimmerberg

Journal, date & volume: FEBS Lett., 2016 Feb 27 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26921878

Abstract
Influenza A virus (IAV) assembles on the plasma membrane where viral proteins localize to form a bud encompassing the viral genome, which ultimately pinches off to give rise to newly formed infectious virions. Upon entry, the virus faces the opposite task-fusion with the endosomal membrane and disassembly to deliver the viral genome to the cytoplasm. There are at least four influenza proteins-hemagglutinin (HA), neuraminidase (NA), matrix 1 protein (M1), and the M2 ion channel-that are known to directly interact with the cellular membrane and modify membrane curvature in order to both assemble and disassemble membrane-enveloped virions. Here, we summarize and discuss current knowledge of the interactions of lipids and membrane proteins involved in the IAV replication cycle.