Channelpedia

PubMed 27029425


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP



Title: Calcium-permeable ion channels in the kidney.

Authors: Yiming Zhou, Anna Greka

Journal, date & volume: Am. J. Physiol. Renal Physiol., 2016 Jun 1 , 310, F1157-67

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/27029425


Abstract
Calcium ions (Ca(2+)) are crucial for a variety of cellular functions. The extracellular and intracellular Ca(2+) concentrations are thus tightly regulated to maintain Ca(2+) homeostasis. The kidney, one of the major organs of the excretory system, regulates Ca(2+) homeostasis by filtration and reabsorption. Approximately 60% of the Ca(2+) in plasma is filtered, and 99% of that is reabsorbed by the kidney tubules. Ca(2+) is also a critical signaling molecule in kidney development, in all kidney cellular functions, and in the emergence of kidney diseases. Recently, studies using genetic and molecular biological approaches have identified several Ca(2+)-permeable ion channel families as important regulators of Ca(2+) homeostasis in kidney. These ion channel families include transient receptor potential channels (TRP), voltage-gated calcium channels, and others. In this review, we provide a brief and systematic summary of the expression, function, and pathological contribution for each of these Ca(2+)-permeable ion channels. Moreover, we discuss their potential as future therapeutic targets.