Referenced in: none

Automatically associated channels: Kv11.1

Title: Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).

Authors: James D Osborne, Thomas P Matthews, Tatiana McHardy, Nicolas Proisy, Kwai-Ming J Cheung, Michael Lainchbury, Nathan Brown, Michael I Walton, Paul D Eve, Katherine J Boxall, Angela Hayes, Alan T Henley, Melanie R Valenti, Alexis K De Haven Brandon, Gary Box, Yann Jamin, Simon P Robinson, Isaac M Westwood, Rob L M van Montfort, Philip M Leonard, Marieke B A C Lamers, John C Reader, G Wynne Aherne, Florence I Raynaud, Suzanne A Eccles, Michelle D Garrett, Ian Collins

Journal, date & volume: J. Med. Chem., 2016 Jun 9 , 59, 5221-37

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/27167172

Abstract