Referenced in: none

Automatically associated channels: Kv11.1

Title: High-performance beating pattern function of human induced pluripotent stem cell-derived cardiomyocyte-based biosensors for hERG inhibition recognition.

Authors: Ning Hu, Tianxing Wang, Qin Wang, Jie Zhou, Ling Zou, Kaiqi Su, Jieying Wu, Ping Wang

Journal, date & volume: Biosens Bioelectron, 2015 May 15 , 67, 146-53

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25153933

Abstract
High-throughput and high clinical relevance methods are demanded to predict the drug-induced cardiotoxicity in pharmaceutical and biotechnology industries to effectively decrease late-stage drug attrition. In this study, human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) were integrated into an interdigital impedance sensor array to fabricate a high performance iPSC-CM-based biosensor array with high-throughput and high-consistency beating pattern. Typical withdrawal approved drugs (astemizole, sertindole, cisapride, and droperidol) with hERG inhibition and positive control E-4031 were employed to determine the beating pattern function. From the results, it can be concluded that this iPSC-CM-based biosensor array can specifically differentiate the hERG inhibitors from the non-hERG inhibition compounds through beating pattern function.