Referenced in: none

Automatically associated channels: Slo1

Title: Polysaccharides of Dendrobium officinale induce aquaporin 5 translocation by activating M3 muscarinic receptors.

Authors: Xiang Lin, Jingyi Liu, Wingyan Chung, Stephen Cho-Wing Sze, Haiyan Li, Lixing Lao, Yanbo Zhang

Journal, date & volume: Planta Med., 2015 Jan , 81, 130-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25590366

Abstract
Dendrobium officinale is an herbal medicine that has been clinically used to promote body fluid production. Previous works demonstrated that D. officinale polysaccharides could ameliorate symptoms of salivary secretion of patients with Sjögren's syndrome and in a respective mice model. In the present study, we investigated the underlying mechanism by which D. officinale polysaccharides activate M3 muscarinic receptors and induce extracellular calcium influx, leading to the translocation of aquaporin 5, a water channel protein, to the apical membrane of human submandibular gland epithelial cells. Enzymatic treatment of D. officinale polysaccharides suggested that they are hydrolyzed but do not permeate cell membranes. This finding supports the pharmacological activity of D. officinale polysaccharides to promote salivary secretion.