Referenced in: none

Automatically associated channels: Slo1 , TASK1

Title: Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.

Authors: Katja K Schneider, Lilian Hüle, Andrea B Schote, Jobst Meyer, Christian Frings

Journal, date & volume: Neuroreport, 2015 Mar 4 , 26, 186-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25674902

Abstract
Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.