Referenced in: none

Automatically associated channels: Kir4.1

Title: Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis.

Authors: Elodie Nerrant, Céline Salsac, Mahmoud Charif, Xavier Ayrignac, Clarisse Carra-Dalliere, Giovanni Castelnovo, Radjiv Goulabchand, Julie Tisseyre, Cédric Raoul, Jean-François Eliaou, Pierre Labauge, Thierry Vincent

Journal, date & volume: Mult. Scler., 2014 Nov , 20, 1699-703

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24756568

Abstract
auto-antibodies against the potassium channel inward rectifying potassium channel 4.1 (Kir4.1) have previously been identified in 46% of patients with multiple sclerosis (MS).to confirm these findings.we evaluated the presence of anti-Kir4.1 antibodies by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence in 268 MS patients, 46 patients with other neurological diseases (OND) and 45 healthy controls.anti-Kir4.1 antibodies were found in 7.5% of MS patients, 4.3% of OND patients and 4.4% of healthy controls. Immunofluorescence analysis did not identify any specific staining.we confirmed the presence of anti-Kir4.1 antibodies in MS patients, but at a much lower prevalence than previously reported.