Referenced in: none

Automatically associated channels: Kv11.1

Title: Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists.

Authors: Bjarne Brudeli, Mirusha Navaratnarajah, Kjetil Wessel Andressen, Ornella Manfra, Lise Román Moltzau, Nils Olav Nilsen, Finn Olav Levy, Jo Klaveness

Journal, date & volume: Bioorg. Med. Chem. Lett., 2014 Sep 15 , 24, 4598-602

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25149506

Abstract
The synthesis and pharmacological data of some new and potent hydrophilic 5-HT4 receptor antagonists are described. Propanediol derivative 25 was identified as a potent antagonist with low affinity for the hERG potassium channel and promising pharmacokinetics.