Referenced in: none

Automatically associated channels: TRP

Title: Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.

Authors: Zhenjian Lin, Michael Koch, May Hamdy Abdel Aziz, Rodrigo Galindo-Murillo, Ma Diarey Tianero, Thomas E Cheatham, Louis R Barrows, Chris A Reilly, Eric W Schmidt

Journal, date & volume: Org. Lett., 2014 Sep 19 , 16, 4774-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25188821

Abstract
A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.