Channelpedia

PubMed 25372600


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPV , TRPV6



Title: The transient receptor potential cation channel subfamily V member 6 (TRPV6): genetics, biochemical properties, and functions of exceptional calcium channel proteins.

Authors: Christof Stoerger, Veit Flockerzi

Journal, date & volume: Biochem. Cell Biol., 2014 Dec , 92, 441-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25372600


Abstract
The transient receptor potential cation channel subfamily V member 6 (TRPV6) gene and cDNA were identified 15 years ago and exceptional observations on TrpV6 proteins and their function as a Ca(2+)-selective cation channel have been made since then. In this review we will summarize recent studies regarding the genetics, biochemical properties, and physiological functions of murine and human TrpV6 channel proteins. We will focus on TRPV6 gene polymorphisms, the start of TRPV6 translation at a non-AUG codon and the functions of TRPV6 in intestinal Ca(2+) uptake, sperm maturation, and male fertility.