Referenced in: none

Automatically associated channels: TASK1

Title: Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning.

Authors: Jun-Hyeok Choi, Pojeong Park, Gi-Chul Baek, Su-eon Sim, Sukjae Joshua Kang, Yeseul Lee, Seo-Hee Ahn, Chae-Seok Lim, Yong-Seok Lee, Graham L Collingridge, Bong-Kiun Kaang

Journal, date & volume: Mol Brain, 2014 , 7, 78

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25373491

Abstract
Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning.