Referenced in: none

Automatically associated channels: Kv11.1

Title: Fluorogenic probe for the human Ether-a-Go-Go-Related Gene potassium channel imaging.

Authors: Zhenzhen Liu, Beilei Wang, Zhao Ma, Yubin Zhou, Lupei Du, Minyong Li

Journal, date & volume: Anal. Chem., 2015 Mar 3 , 87, 2550-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25665091

Abstract
The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off-on mechanism was described herein. After careful biological evaluation, this probe had the potential of detecting and imaging the hERG channel at the molecular and cellular level. Moreover, the competitive binding mechanism of this probe would presumably minimize the effects on the electrophysiological properties of the hERG channel. Therefore, this probe may serve as a powerful toolkit to the hERG-associated study.