Referenced in: none

Automatically associated channels: TRP

Title: Sensory TRP channels: the key transducers of nociception and pain.

Authors: Aaron D Mickle, Andrew J Shepherd, Durga P Mohapatra

Journal, date & volume: Prog Mol Biol Transl Sci, 2015 , 131, 73-118

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25744671

Abstract
Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve fibers. The majority of such molecular detectors/transducers belong to the transient receptor potential (TRP) family of cation channels, which comprise both specific receptors for distinct nociceptive stimuli, as well as for multiple stimuli. This chapter discusses the classification, distribution, and functional properties of individual TRP channel types that have been implicated in various nociceptive and/or painful conditions.