Referenced in: none

Automatically associated channels: Cav3.1 , Cav3.2 , Cav3.3

Title: [Effects of bisphenol A on voltage-dependent T-type calcium channels in mouse testis and epididymis, and the role of estrogen receptors].

Authors: Qiang Wang, Ling Zhang, Zeyuan Ding, Qian Wenyi, Qian Lu, Jun Wang, Hang Xiao

Journal, date & volume: Wei Sheng Yan Jiu, 2015 Jan , 44, 23-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25958630

Abstract
To explore the possible effects of bisphenol A (BPA) on voltage-dependent T-type calcium channels in mouse testis and epididymis, the role of the two ERs was also investigated.Adult male wild type (WT), ERs knock out mice (αERKO and βERKO) were randomly divided into control and BPA [100 μg/(kg. d) for 30 days via intragastric administration] treatment groups. Quantitative real time PCR was used to examine Cav3.1, Cav3.2 and Cav3.3 genes of the testis and epididymis.In the testis, the mRNA expression of Cav3.1, Cav3.2 and Cav3.3 were increased in BPA-treated animals. In the epididymis, the mRNA expression of Cav3. 1 and Cav3.2 were increased, however, Cav3.3 were decreased in BPA-treated animals. BPA up-regulation of Cav3.1 and Cav3.2 mRNA expression of the epididymis were dependent on both ERα and ERβ, whereas BPA regulation of Cav 3.1 - Cav3.3 of the testis and Cav3.3 of the epididymis appeared to be dependent on ERβ only.It suggested that the ERs signalling was necessary for the regulation of the Cav3 channels mRNA expression by BPA, which could affect the male reproductive function.