Channelpedia

PubMed 26411616


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir6.2



Title: Multigene Family Evolution: Perspectives from Insect Chemoreceptors.

Authors: Richard Benton

Journal, date & volume: Trends Ecol. Evol. (Amst.), 2015 Oct , 30, 590-600

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26411616


Abstract
Understanding the birth and diversification of multigene families is a fundamental evolutionary problem. I argue for the insect chemoreceptor superfamily as an outstanding model. Although these receptors are currently the preserve of neuroscientists, putative homologous genes exist in diverse animal and plant genomes, implying an ancient origin. Moreover, functional studies suggest that they act as ligand-gated ion channels in both chemosensory and non-chemosensory processes. This family permits synergism of investigations into its structural and regulatory evolution with ecological studies of the selective pressures driving these changes. In addition, sequence divergence in these receptors can be exploited through co-evolutionary and comparative genomics analyses to help to elucidate their 3D structure and signaling mechanisms, and to reveal experimentally-accessible candidate loci to explore the genetic basis of adaptation.