Referenced in: none

Automatically associated channels: TRP

Title: A network perspective on unraveling the role of TRP channels in biology and disease.

Authors: Jung Nyeo Chun, Jin Muk Lim, Young Kang, Eung Hee Kim, Young-Cheul Shin, Hong-Gee Kim, Dayk Jang, Dongseop Kwon, Soo-Yong Shin, Insuk So, Ju-Hong Jeon

Journal, date & volume: Pflugers Arch., 2014 Feb , 466, 173-82

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23677537

Abstract
Transient receptor potential (TRP) channels are a large family of non-selective cation channels that mediate numerous physiological and pathophysiological processes; however, still largely unknown are the underlying molecular mechanisms. With data generated on an unprecedented scale, network-based approaches have been revolutionizing the way in which we understand biology and disease, discover disease genes, and develop therapeutic strategies. These circumstances have created opportunities to encounter TRP channel research to data-intensive science. In this review, we provide an introduction of network-based approaches in biomedical science, describe the current state of TRP channel network biology, and discuss the future direction of TRP channel research. Network perspective will facilitate the discovery of latent roles and underlying mechanisms of TRP channels in biology and disease.