Referenced in: none

Automatically associated channels: Kv1.5

Title: [Long term outcome of atrial fibrillation patients with KCNA5 and NPPA mutations post circumferential pulmonary vein ablation].

Authors: Rong-feng Zhang, Yun-long Xia, Chu-chu Wang, Lian-jun Gao, Xiao-meng Yin, Dong Chang, Pei-xin Cong, Ying-xue Dong, Shu-long Zhang, Xin Tu, Qing Wang, Yan-Zong Yang

Journal, date & volume: Zhonghua Xin Xue Guan Bing Za Zhi, 2013 May , 41, 387-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24021120

Abstract
The outcome of atrial fibrillation patients with genetic mutations post ablation was not well evaluated.Three atrial fibrillation patients with evidence of mutations in KCNA5 and NPPA post successful circumferential pulmonary vein ablation were included. Mutation in KCNA5 was found in one male patient with paroxysmal atrial fibrillation. He was free of atrial fibrillation post ablation after 46 months follow-up. Mutations in NPPA were found in two male patients with persistent atrial fibrillation and they were free from atrial fibrillation after 64 months and 38 months follow-up post circumferential pulmonary vein ablation, roof line and mitral isthmus line ablation.Satisfactory long term results are observed in atrial fibrillation patients with KCNA5 and NPPA mutations post circumferential pulmonary vein ablation.