Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Sensory nerves and transient receptor potential vanilloid 1 channels in CO(2) regulation of cerebrovascular tone.

Authors: SeongHun Yoon, Mario Zuccarello, Robert M Rapoport

Journal, date & volume: Respir Physiol Neurobiol, 2014 May 1 , 195, 41-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24548973

Abstract
This study investigated the involvement of sensory nerves and, in particular, neuronal transient receptor potential vanilloid (TRPV) 1 channels, in the CO(2)-mediated regulation of cerebrovascular tone. Basilar artery diameter and blood flow velocity in the ventral midbrain were determined in a rat cranial window preparation by digital imaging and laser-Doppler flowmetry, respectively. Superfusion of the basilar artery with capsaicin, a selective TRPV1 receptor agonist, caused a transient relaxation, consistent with acute desensitization of neuronal TRPV1 channels. Constriction to respiratory hypocapnia remained unaffected following capsaicin superfusion. Denervation of sensory nerves by repeated capsaicin injection of neonates also did not reduce the respiratory hypocapnia constriction of the basilar artery as well as the decreased flow velocity in the ventral midbrain in adults. These findings suggest that sensory nerves and, in particular, neuronal TRPV1 channels, do not play a role in respiratory hypocapnia constriction and decreased flow, at least in rat basilar artery and ventral midbrain.