Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM7

Title: TRPM7 is involved in angiotensin II induced cardiac fibrosis development by mediating calcium and magnesium influx.

Authors: Yang Yu, Shaorui Chen, Chuyao Xiao, Yanyan Jia, Jinlei Guo, Jianmin Jiang, Peiqing Liu

Journal, date & volume: Cell Calcium, 2014 May , 55, 252-60

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24680379

Abstract
Cardiac fibrosis is involved in a lot of cardiovascular pathological processes. Cardiac fibrosis can block conduction, cause hypoxia, strengthen myocardial stiffness, create electrical heterogeneity, and hamper systolic ejection, which is associated with the development of arrhythmia, heart failure and sudden cardiac death. Besides the initial stimulating factors, the cardiac fibroblasts (CFs) are the principal responsible cells in the fibrogenesis cascade of events. TRPM7, a member of the TRPM (Melastatin) subfamily, is a non-selective cation channel, which permeates both Ca(2+) and Mg(2+). Here we demonstrated TRPM7 expression in CFs, and 2-APB (TRPM7 inhibitor), inhibited Ang II-induced CTGF, α-SMA expression and CFs proliferation. Besides, knocking down TRPM7 by shRNA, we proved that TRPM7 mediated both calcium and magnesium changes in cardiac fibroblasts which contribute to fibrosis progress. This study suggested that TRPM7 should play a pivotal role in cardiac fibroblast functions associated to cardiac fibrosis development.