Referenced in: none

Automatically associated channels: Cav1.3

Title: ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.

Authors: Simon Weiler, Stefanie Krinner, Aaron B Wong, Tobias Moser, Tina Pangrsic

Journal, date & volume: J. Neurosci., 2014 May 14 , 34, 6843-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24828638

Abstract
Sound encoding is mediated by Ca(2+) influx-evoked release of glutamate at the ribbon synapse of inner hair cells. Here we studied the role of ATP in this process focusing on Ca(2+) current through CaV1.3 channels and Ca(2+) homeostasis in mouse inner hair cells. Patch-clamp recordings and Ca(2+) imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca(2+) influx in inner hair cells via fueling Ca(2+)-ATPases to avoid an increase in cytosolic [Ca(2+)] and subsequent Ca(2+)/calmodulin-dependent inactivation of CaV1.3 channels.