Referenced in: none

Automatically associated channels: Kv11.1

Title: Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.

Authors: Jun Yun, Minsoo Han, Chiman Song, Seung Hoon Cheon, Kihang Choi, Hoh-Gyu Hahn

Journal, date & volume: Bioorg. Med. Chem. Lett., 2014 Aug 1 , 24, 3234-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24974340

Abstract
We report the synthesis of 3-phenethylazetidine derivatives 2 and their biological activities against 5-HT, NE and DA transporters as well as microsomal stability, CYP inhibition, and hERG inhibition profiles. Compound 2at showed most potent triple reuptake inhibitor with good selectivity as a candidate for depression.