Channelpedia

PubMed 24992765


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir6.1



Title: Total flavonoids from Ganshanbian (Herba Hyperici Attenuati) effect the expression of CaL-alpha1C and K(ATP)-Kir6.1 mRNA of the myocardial cell membrane in myocardial ischemia-reperfusion arrhythmia rats.

Authors: Yuxuan Ma, Yanli Wang, Yanyu Gao, Yin Fu, Ji Li

Journal, date & volume: J Tradit Chin Med, 2014 Jun , 34, 357-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24992765


Abstract
To observe the impact of total flavonoids from Ganshanbian (Herba Hyperici Attenuati) on the expression of vascular smooth muscle membrane L-type calcium channel alpha1 C subunit (CaL-alpha1C) and ATP-sensitive K+ channel (K(ATP))-Kir6.1 mRNA, and explore the mechanisms of the antiarrhythmic effect of Ganshanbian (Herba Hyperici Attenuati) total flavonoids.The treatment group was fed total flavonoids from Ganshanbian (Herba Hyperici Attenuati) for 7 days by gavage with 100 mg x kg(-1) x d(-1). The blank control group and model control group were given the same amount of normal saline for 7 d. Arrhythmias were induced by performing a myocardial ischemia-reperfusion and electrocardiogram was observed. Reverse transcription-polymerase chain reaction was used to detect the expression of CaL-alpha 1C and K(ATP)-Kir6.1 mRNA in the myocardial cell membrane of all groups of rats.Total flavonoids from Ganshanbian (Herba Hyperici Attenuati) can delay the appearance of myocardial ischemia reperfusion arrhythmias, shorten the duration of myocardial ischemia reperfusion arrhythmias, reduce heart rate, reduce cell membrane expression of CaL-a1C mRNA and enhance the expression of K(ATP)-Kir6.1 mRNA in myocardial ischemia-reperfusion arrhythmic rats.Total flavonoids from Ganshanbian (Herba Hyperici Attenuati) can alleviate arrhythmias by affecting the expression of L-type calcium channels and ATP-sensitive K+ channels.