Referenced in: none

Automatically associated channels: Nav1.1

Title: [Src family kinases affect the expression of Nav1.1 in spiral ganglion neurons].

Authors: Qingjiao Zeng, Huiying Chen, Jiping Su

Journal, date & volume: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2014 Jun , 28, 789-92

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25219203

Abstract
To investigated the effects of Src family kinases on the expression of mRNA and protein of Nav1.1 in spiral ganglion neurons.RT-PCR and Western blot techniques respectively explored the level of expression of mRNA and protein of Nav1.1 in spiral ganglion neurons by Src family kinases inhibitor.An application of the inhibitor of Src family kinases which was PP2 (10 micromol/L) and SU6656 (2 micromol/L) gived rise to the mRNA decreasing to 26% +/- 0.8% and 36% +/- 1.5% respectively (P < 0.05), and protein reducing to 39% +/- 12.5% and 53% +/- 1.7% severally (P < 0.05).Administration of the inhibitor of Src family kinases could decrease the expression of mRNA and protein of Nav1.1 in spiral ganglion neurons.