Referenced in: none

Automatically associated channels: Nav1.7

Title: Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker.

Authors: Zhi-Yong Tan, Birgit T Priest, Jeffrey L Krajewski, Kelly L Knopp, Eric S Nisenbaum, Theodore R Cummins

Journal, date & volume: FEBS Lett., 2014 Nov 3 , 588, 3964-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25240195

Abstract
Resurgent sodium currents likely play a role in modulating neuronal excitability. Here we studied whether protein kinase C (PKC) activation can increase resurgent currents produced by the human sodium channel hNav1.7. We found that a PKC agonist significantly enhanced hNav1.7-mediated resurgent currents and this was prevented by PKC antagonists. The enhancing effects were replicated by two phosphorylation-mimicking mutations and were prevented by a phosphorylation-deficient mutation at a conserved PKC phosphorylation site (Serine 1479). Our results suggest that PKC can increase sodium resurgent currents through phosphorylation of a conserved Serine residue located in the domain III-IV linker of sodium channels.