Referenced in: none

Automatically associated channels: TRP

Title: General flexible nature of the cytosolic regions of fungal transient receptor potential (TRP) channels, revealed by expression screening using GFP-fusion techniques.

Authors: Makoto Ihara, Yoshitaka Takano, Atsuko Yamashita

Journal, date & volume: Protein Sci., 2014 Jul , 23, 923-31

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24723374

Abstract
Transient receptor potential (TRP) channels are members of the voltage gated ion channel superfamily and display the unique characteristic of activation by diverse stimuli. We performed an expression analysis of fungal TRP channels, which possess relatively simple structures yet share the common functional characteristics with the other members, using a green fluorescent protein-based screening methodology. The analysis revealed that all the tested fungal TRP channels were severely digested in their cytosolic regions during expression, implying the common flexibility of this region, as observed in the recent structural analyses of the fungal member, TRPGz. These characteristics are likely to be important for their diverse functions.