Referenced in: none

Automatically associated channels: Kv4.1 , Slo1

Title: Krüppel mediates the selective rebalancing of ion channel expression.

Authors: Jay Z Parrish, Charles C Kim, Lamont Tang, Sharon Bergquist, Tingting Wang, Joseph L Derisi, Lily Yeh Jan, Yuh Nung Jan, Graeme W Davis

Journal, date & volume: Neuron, 2014 May 7 , 82, 537-44

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24811378

Abstract
Ion channel gene expression can vary substantially among neurons of a given type, even though neuron-type-specific firing properties remain stable and reproducible. The mechanisms that modulate ion channel gene expression and stabilize neural firing properties are unknown. In Drosophila, we demonstrate that loss of the Shal potassium channel induces the compensatory rebalancing of ion channel expression including, but not limited to, the enhanced expression and function of Shaker and slowpoke. Using genomic and network modeling approaches combined with genetic and electrophysiological assays, we demonstrate that the transcription factor Krüppel is necessary for the homeostatic modulation of Shaker and slowpoke expression. Remarkably, Krüppel induction is specific to the loss of Shal, not being observed in five other potassium channel mutants that cause enhanced neuronal excitability. Thus, homeostatic signaling systems responsible for rebalancing ion channel expression can be selectively induced after the loss or impairment of a specific ion channel.