Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Quinolines: a new hope against inflammation.

Authors: Soumita Mukherjee, Manojit Pal

Journal, date & volume: Drug Discov. Today, 2013 Apr , 18, 389-98

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23159484

Abstract
Although a number of anti-inflammatory drugs have been discovered and developed to treat diseases associated with acute and chronic inflammation, many anti-inflammatories cause adverse side effects. The quinoline framework has emerged as a new template for the design and identification of novel anti-inflammatory agents. These agents are classified based on the number of substituents present on the quinoline ring or compounds containing a quinoline ring fused to other heterocycles. This review focuses on the discovery of various quinoline derivatives as inhibitors of cyclooxygenase (COX), phosphodiesterase 4 (PDE4) and tumour necrosis factor-α converting enzyme (TACE), along with transient receptor potential vanilloid 1 (TRPV1) antagonists.