Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC3

Title: Transient receptor potential canonical type 3 channels--their evolving role in hypertension and its related complications.

Authors: Peijian Wang, Daoyan Liu, Martin Tepel, Zhiming Zhu

Journal, date & volume: J. Cardiovasc. Pharmacol., 2013 Jun , 61, 455-60

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23364606

Abstract
: Recent studies indicate that transient receptor potential canonical type 3 (TRPC3) channels contribute to the regulation of blood pressure and vascular and renal function. Several studies show that TRPC3 dysfunction is associated with hypertension, atherosclerosis, cardiac hypertrophy, and cerebrovascular events. In this review, we summarize the role of TRPC3 channels in the cardiovascular system, and we focus on their pathophysiological role in hypertension and related target organ damages. We provide new insight into the involvement of TRPC3 channels in the development of hypertension and its related complications.