Referenced in: none

Automatically associated channels: Kir2.3

Title: Pharmacology of carvedilol.

Authors: Brian Dulin, William T Abraham

Journal, date & volume: Am. J. Cardiol., 2004 May 6 , 93, 3B-6B

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15144929

Abstract
Carvedilol is a third-generation, neurohormonal antagonist with multiple activities. It blocks both beta(1)- and beta(2)-adrenergic receptors, enhances vasodilation via alpha(1)-adrenergic blockade, and, at high concentrations, has ion channel-blocking activities. Carvedilol lacks sympathomimetic activity. In addition to these well-known properties, carvedilol has a number of ancillary activities, including antioxidant, anti-inflammatory, and antiapoptotic properties. Together, they contribute to the clinical efficacy of carvedilol in a broad spectrum of patient types and may also confer a range of cardioprotective benefits.