Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: [Characterization of afferent neurons of spinal ganglions sensitive to capsaicin].

Authors: V V Porseva

Journal, date & volume: Tsitologiia, 2012 , 54, 887-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23461032

Abstract
Morphological features of TRPV1(+)-, SP(+)-, CGRP(+)-, NF200(+)-neurons has been studied in thoracic spinal ganglions in 3-month-old rats under chemical deafferentation. The results have shown that from 6.5 up to 41.3% of ganglionic neurons of control group had markers mentioned above. The heterogeneity of nociceptive neurons in control group was kept in capsaicin-treated animals. In both groups, TRPV1(+)-neurons were prevailed, populations of SP(+)-, CGRP(+)- and NF200(+)-neurons formed smaller groups. Sensitivity to capsaicin was shown in largest neurons in each population; neurons in experimental group had smaller cross-sectional area, particularly in group of TRPV1(+)-neurons.