Referenced in: none

Automatically associated channels: Kir6.2 , Slo1

Title: The gain modulation by N-methyl-D-aspartate in the projection neurons of robust nucleus of the arcopallium in adult zebra finches.

Authors: Su-Qun Liao, Guo-Qiang Hou, Xuan Pan, Cong-Shu Liao, Dong-Feng Li

Journal, date & volume: Neural Plast., 2012 , 2012, 931780

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22685680

Abstract
The song of zebra finch is stable in life after it was learned successfully. Vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. The activity of RA, an important pre-motor nucleus in songbird's brain, influences the song directly. This variability in adult birdsong is associated with the activity of NMDA receptors in LMAN-RA synapses, but the detailed mechanism is unclear. The control of gain refers to modulation of a neuron's responsiveness to input and is critically important for normal sensory, cognitive, and motor functions. Here, we observed the change of gain in RA projection neurons after exogenous NMDA was applied to activate NMDA receptors using the whole-cell current clamp recording. We found that NMDA substantially increased the slope (gain) of the firing rate-current relationship in RA projection neurons. The AMPA receptor-dependent excitability played a crucial role in the modulation of gain by NMDA. These results suggested that NMDA receptors may regulate the dynamics of RA projection neurons by input-output gain.