Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV6

Title: Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer.

Authors: Amelia A Peters, Peter T Simpson, Johnathon J Bassett, Jane M Lee, Leonard Da Silva, Lynne E Reid, Sarah Song, Marie-Odile Parat, Sunil R Lakhani, Paraic A Kenny, Sarah J Roberts-Thomson, Gregory R Monteith

Journal, date & volume: Mol. Cancer Ther., 2012 Oct , 11, 2158-68

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22807578

Abstract
Calcium signaling is a critical regulator of cell proliferation. Elevated expression of calcium channels and pumps is a characteristic of some cancers, including breast cancer. We show that the plasma membrane calcium channel TRPV6, which is highly selective for Ca(2+), is overexpressed in some breast cancer cell lines. Silencing of TRPV6 expression in a breast cancer cell line with increased endogenous TRPV6 expression leads to a reduction in basal calcium influx and cellular proliferation associated with a reduction in DNA synthesis. TRPV6 gene amplification was identified as one mechanism of TRPV6 overexpression in a subset of breast cancer cell lines and breast tumor samples. Analysis of two independent microarray expression datasets from breast tumor samples showed that increased TRPV6 expression is a feature of estrogen receptor (ER)-negative breast tumors encompassing the basal-like molecular subtype, as well as HER2-positive tumors. Breast cancer patients with high TRPV6 levels had decreased survival compared with patients with low or intermediate TRPV6 expression. Our findings suggest that inhibitors of TRPV6 may offer a novel therapeutic strategy for the treatment of ER-negative breast cancers.